Coming up at night especially during the winter, your best bet is probably 89 to Exit 9, then 100B to 100 South. You could get off at Exit 3 and go 107W to 100N, but a large portion of that route is no-man's land. If something happens, your cell phone (if you have one) won't work for most of the way and there isn't much to see. Plus, services are few and far between. After Rochester, its 20 miles or so of "absolutely nothing" until you hit the MRV.
Then there are always the "mountain roads" such as Roxbury Gap, etc, but I'd advise against them, especially if you're not familiar with the area. Driving past the secondary roads to work, many of them are still quite snow covered and most likely ice.
Whatever way you choose, be safe and enjoy the weekend!
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